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Because letrozole does not deplete estrogen receptors, as clomiphene citrate does (3), normal central feedback mechanisms are intact. As the dominant follicle grows and estrogen levels increase,. If you have late ovulation and you want to get pregnant, talk with your doctor about the use of drugs such as clomiphene and letrozole that stimulate ovulation. Objective: this study was designed to compare the effectiveness of clomiphene, tamoxifen and letrozole in ovulation induction outcomes in isolated non pcos unovulatory patients. Materials and methods: 150 unovulatory infertile women who had isolated non- polycystic ovarian syndrome (pcos), randomized to 3 groups. Femara (generic name is letrozole) is an oral drug which can be an effective fertility treatment for women with ovulation problems, or for those with unexplained infertility. This medication is in a class of drug called aromatase inhibitors. Femara has mainly been used to treat certain cases of breast cancer. Women who received the combination of letrozole and cc had a statistically higher ovulation rate compared with those who received letrozole alone (27 of 35 women [77%] vs. 15 of 35 women [43%]). There were no serious adverse events or multiple-gestation pregnancies in either group. The reason for this was lower dose of letrozole. Once i found the right dose,that worked for me, i had decent size follicle on cd 12. Letrozole helped move my ovulation up from cd 25 to now cd 14-15. My provider told me not to start checking opks until cd10 bc letrozole can affect them & show lh higher than normal. Do you have pics of your opks? 0. What are these fertility drugs and what do they do? it has now become clear that letrozole is the medicine of choice if you do not ovulate. Women with pcos (polycystic ovary syndrome) who need help ovulating tend to have the best success when using letrozole with timed intercourse in order to achieve a live birth. 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