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TAPENTADOL safety information
In the key food-effect study (PAI-1020/HP28) that evaluated the effect of tapentadol liver nucynta tab 50mg tapentadol fass nucynta vs opana nucynta in your system tapentadol a high-fat, high-calorie breakfast on the single dose bioavailability of tapentadol at the highest to-be-marketed dose strength of 250 mg, there was no significant effect on the AUC parameters (8% higher in fed state) of tapentadol .
A small increase, estimated from the analysis of variance tapentadol (ANOVA), of about 18% in Cmax was observed .
However, tapentadol since this increase was still well within the inter-subject variability for Cmax of tapentadol observed in this study (30-33%), the increase in Cmax was not expected to have an impact on safety or efficacy .
Similar results were obtained in an earlier, supportive tapentadol slow release dosage nucynta and grapefruit juice tapentadol moa nucynta generic date study (PAI-1003/HP17) using the higher dose of 300 mg tapentadol SR2 .
In this study, the mean Cmax in the fed state was 28% higher nucynta class tapentadol urine test palexia use nucynta er 150 mg nucynta launch nucynta heart than in the fasted state, but again there was no significant change in AUC between the fasted and fed states .
Data from the key food-effect study (PAI-1020/HP28) was compared to the pooled pharmacokinetic tapentadol data obtained in the fasted condition .
Since the key food effect study was conducted tapentadol at the highest recommended dose of 250 mg, the AUCs of the pooled pharmacokinetic data were also normalised to a 250 mg dose .
No dose normalisation nucynta package insert tapentadol price uk tapentadol 100mg tapentadol scheduled drug class was applied for Cmax and hence the comparison of Cmax is more limited .
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